Entering edit mode
2.5 years ago
mincej20
•
0
I'm working with HGU133Plus2 datasets, and I'm determining the best normalization procedures.
RMA seems to be the standard in literature, however some papers have been opting away from global normalization procedures:
I'm not familiar with how the statistics with RMA works. So my question is: Can I apply RMA on each disease group separately, and combine them afterwords? Or would an algorithm that accounts for disease label differences (i.e. qsmooth) be a better option?
Thanks for any help