Mendelian randomization outcome data screen

Question

[celia]

Hello everyone

I performed a two-sample MR on thyroid function and a kind of disorder. The reviewers asked me about the outcome data screen: "Participants in the GWAS for this kind of disorder could have been taking thyroid medicine(like Levothyroxine). How would this have affected the interpretation of the MR result?"

Please help me with this comment.