I would really appreciate your help as I am new to working with different file builds and having a setback lifting a vcf file from build hg38 to hg19. in essence, using CrossMap the chromosome value gets altered. Like for example, below is the code:
CrossMap.py vcf hg38ToHg19.over.chain.gz inpute_hg38.vcf.gz hg19.fa.gz output.hg19.vcf
The output file has the value
chr1_gl000192_random 526406 chr1:149144526:SG G A .
While the file have the value
chr1 149144526 chr1:149144526:SG G A
The change happens in the CHROM value after using CrossMap. This change stops me from being able to combine all different vcf files for furthiur analysis. Any idea why this is happening or how to stop it?