Deleted:High heterozygosity after imputation of single sample
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3 months ago

Dear all,

I imputed genotypes for a single person using Michigan Imputation Server. I used the following settings:

  • Build: hg19
  • Reference Panel: apps@hrc-r1.1 (hg19)
  • Population: eur
  • Phasing: eagle
  • Mode: imputation
  • Rsq filter: 0.3

As a result, almost all SNP were imputed as heterozygotes. I found this strange, because before, when I used this server to impute something else, some cohort of data, I have never met such problem.

How can I explain this situation and how I can fix it? Maybe some of you faced it.

heterozygosity imputation • 93 views
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