Entering edit mode
2.2 years ago
Bogdan
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1.4k
Dear all,
would you please let me know, based on your experience, how reliable are the inter-chromosomal interactions called by 4C techniques ? Thank you.
~ Bogdan
Bogdan - I would be happy to, but could you please describe (approximately) your goals for the experiment? It will help me to describe the reliability.
Thank you Vincent. I would like to evaluate whether 4C can capture the inter-chromosomal contacts that have been characterized in MCF7 cells after estradiol treatment. For example, in the publication :
https://www.pnas.org/content/105/49/19199.long
the authors describe the interactions between TFF1 and GREB1 gene loci that are located on different chromosomes (figure 4). Thank you.