Converting observed heritability to liability scale, how to get standard error?
0
0
Entering edit mode
2.2 years ago
curious ▴ 750

Using greml I get snp heritability for binary trait of 0.029642 with standard error of 0.006261.

I know I can convert SNP heritability to liability scale like this:

#K=pop prevalence
#P=proportion of cases in study
#hsq=Heritability estimate (on observed scale)
#bigT = liability threshold
#tau = density of gaussian
K=my pop prev.
P=my proportion of cases
h2=0.029642
zv <- dnorm(qnorm(K))

h2_liab <- h2 * K^2 * ( 1 - K)^2 / P / (1-P) / zv^2

But how do I get standard error on the liability scale or is it just the same as the SNP heritability standard error. Thanks!

hertiability greml ldsc • 552 views
ADD COMMENT

Login before adding your answer.

Traffic: 1777 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6