Finemapping - multiple causal SNPs, only one GWAS significant
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2.0 years ago
J ▴ 20

Per the title, I have been attempting some fine mapping with a new release of summary statistics and previously straight forward loci now have multiple causal SNPs, typically only one of which is GWAS significant. What does one do in such a situation? Can one say that only the gwas significant snp is causal or must one consider all of them? Hoping to get a publication out of this if possible.

gwas finemapping finemap • 351 views
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