Combining single and paired end reads for SNP calling?
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2.0 years ago
bio-jr ▴ 10

Hello all, We have a diversity panel consisting of around 500 genotypes. Half of these genotypes are single end and the rest half of them are paired-end DNA sequences. We are interested in creating a single SNP dataset for the diversity panels by combining both single and paired-end sequencing sets of genotypes. Will it be possible to process these two datasets for SNP calling? What would be the best approach to deal with these situations?

I truly appreciate your suggestions and guidance. Thanks in advance for any attempts to help.

SNP Calling • 360 views
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