I am blasting some predicted peptides against the Uniprot database, and many of the hits are "Uncharacterized Protein". How is this designation chosen? i.e. what level of evidence is required for a peptide sequence to be added to the database and given this designation rather than be excluded?
I don't see it described on Uniprot website. I tried to read the publication to see where this term is explained, but there are a crazy number of pubs going back to 1997 (and I can't access that one) https://www.uniprot.org/help/publications