Convert a gene into amino sequences

Question

[vpsev3]

Hello,

I'm trying to convert a gene (DNA) into a protein (amino acids)

I tried to convert them but I have a lot more amino acids than here for example https://alphafold.ebi.ac.uk/entry/Q8W3K0

This is what I tried https://web.expasy.org/translate/

I try to find a software where I just have to enter the sequence and I will have the result

Answer 1

[GenoMax]

If this is a known gene then you don't need to do this manually. e.g. https://www.ncbi.nlm.nih.gov/nuccore/NM_000207.3/ is human insulin. If you look at the record you will find a link for protein sequence NP_000198.1 in that record. Or you could simply search for protein sequence directly using the name of the gene.

[vpsev3]

Thank you it works

Answer 2

[Laura Luebbert]

If you have the Ensembl IDs of the genes, you can use gget seq:

pip install gget
gget seq -t ENSG00000034713 ENSG00000104853 ENSG00000170296

or from a Python environment:

!pip install gget
import gget
gget.seq(["ENSG00000034713", "ENSG00000104853", "ENSG00000170296"], translate=True)

This returns the amino acid sequences of the canonical transcripts of the passed genes in FASTA format. You can also use isoforms=True to return the amino acid sequences of all known transcripts.