Position Summary This position assists with the technical aspects of studies and experiments, including documentation, preparation of materials, performing experiments and delivery of reports.
This research broadly deals with understanding the neuropathology of Alzheimer Disease (AD). AD is characterized by the deposition of protein aggregates that interfere with neuronal synapsis, cause inflammation and eventual cell death. Genomic and other large omics technologies are identifying novel potential players in the pathology of AD. These omics-driven studies will be complimented by performing functional analysis to confirm the actual role of these in-silico discoveries and determine their exact role in the pathogenesis of AD. For that purpose, we generate induced pluripotent stem cell (iPSC)-derived neural models (neuron, astrocyte, microglia), modify the expression of genes of interest in these cell models, and evaluate the possible consequences of such modification on the main pathways involved in the pathology of AD. Job Description Primary Duties and Responsibilities
Assists with research studies, experiments and assays, including collection of data, preparation of solutions and set-up and maintenance of equipment. Performs data entry and maintains data files on research. Prepares tissue cultures, reagents, probe tests, etc. Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions. Ensures lab conditions and equipment are properly cleaned and maintained in accordance with established procedures. Assists with general lab maintenance and cleaning. Performs other duties as assigned. Working Conditions
This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Experience in a laboratory setting working with iPSC cell culture.
Knowledge of the brain system and its cell types.
Experience in differentiation of iPSC into neural cell lines.
Experience with DNA extraction, PCR/qPCR, ELISA, ICC/IHC/IF, and gene editing techniques (transduction, transfection, CRISPR).
Some level of training in biological sciences and/or with prior experience engaging in collaborative biological projects.
Effective verbal, written and interpersonal communication skills with the ability to present on various research topics to internal or external audiences.
Demonstrated ability as a self-starter with strong critical thinking and attention to detail.
Demonstrated ability to maintain complete and organized records/reports.
Demonstrated ability and knowledge of computer software & lab equipment, including statistical software, spreadsheets, and lab management systems. Ability to work in a lab research environment. Required Qualifications Bachelor’s degree and up to one year of experience in a laboratory setting or an equivalent combination of education and experience equaling four years.
Grade R06-H Salary Range $16.08 - $25.12 / Hourly The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget. Accommodation If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.
Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits Statement Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits. EEO/AA Statement Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. Diversity Statement Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.