Sample size for population genetics

Question

[zimmer.schweiz]

In population genetics, what sample size would one ideally need to get enough clarity to study the effects of genetic mutations and also to overlap these findings with other layers of the omics (e.g. transcriptomics) in order to understand the underlying biology?

Answer 1

[Jeremy Leipzig]

For a rare penetrant monogenic disease? A few cases. For a common polygenic disease or trait? 500k-10M

[zimmer.schweiz]

Thank you so much for your answer. For common polygenic diseases, would it make sense to increase the number of populations sampled, in order to be able to work with a smaller sample size?

[Jeremy Leipzig]

Other populations just make the model harder to generalize, not easier.