ABSOLUTE for tumour purity with WES

Question

[Cvlind]

Hello,

I have WES paired data (tumour and normal) from Illumina sequencing and I would like to obtain a purity score.

ABSOLUTE seemed perfect but I can't get it to work. Here's my workflow:

1. Generate .pileup from .bam with SamTools
2. Generate .copynumber from .pileup with VarScan
3. Generate .seg from .copynumber with DNAcopy (R)
4. Use ABSOLUTE (R)

I found a lot of posts out there, but a majority of them are still unanswered and quite old (this is the error I'm getting now and can't get rid of: WES samples failing ABSOLUTE)

It's quite old now and I was wondering if it's still in use today, or if not what are the best alternatives?

Thanks!