Entering edit mode
15 months ago
caique.manochio
•
0
Hi, I have some vcf files in which some ref alleles are different for the same region. Can I merge all vcf files or do I have to standardize these ref alleles?
Normalize them first using
vt normalize
orbcftools norm
- they need to be in left-aligned parsimonious representation before you can do an accurate merge if required.Thank you!