Entering edit mode
2.3 years ago
kts.desilva
•
0
Hello!
I got this confusion regarding the concept and intuition behind normalizing an entire set (having multiple TMT plexes) of experiment which contains both healthy and tumor together.
Because for normlization, we aim to have a common range for all samples but how can we verify that the differences between healthy and tumor are not eliminted or disorted by simply normalizing.
I have seen couple of papers [1], 2doing this and achiving plausible results, but still I'm not convinced about the intuition behind this apparoch.
What am I missing here? Please clarify.
Thank you!
