Are the GRCh38.p12 and GRCh38.p13 using the same sequence?

Question

[qwesxadzc9]

I was wondering are the human annotation GRCh38.p12 and GRCh38.p13 using the same sequence and share the same genomic coordinates? Thanks in advance

[Jeremy Leipzig]

We keep seeing these patch vs freeze questions and I'd like to see u/48443/ pay this question forward.

Answer 1

[GenoMax]

Yes they are using the same sequence for main chromosomes. See: Understanding Used Assembly: Why aren't authors specific about patch version?

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Patches are accessioned scaffold sequences that represent assembly updates. They add information to the assembly without disrupting the chromosome coordinates. Patch releases are cumulative.

Full revision history of patch accessions at the bottom of this page: https://www.ncbi.nlm.nih.gov/datasets/genome/GCA_000001405.29/