News:Cellosaurus release 48 is available
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10 weeks ago
Amos Bairoch ▴ 120

Cellosaurus release 48 is available at https://www.cellosaurus.org/

1) Statistics

  • 152231 cell lines (112768 human, 27420 mouse, 2879 rat)
  • 809 species represented
  • 112476 synonyms
  • 453478 cross-references to 108 resources (cell line catalogs, databases, ontologies, etc.)
  • 158453 references to 27418 distinct publications (papers, patents, theses, etc.)
  • 13492 web links
  • 8734 human, mouse and dog cell lines with STR profiles (from 856 distinct sources)
  • 2434 NCIt and 1339 ORDO (Orphanet) disease terms cited
  • 831 UBERON and 258 CL terms cited

Since release 47 of October 2023: 3553 entries were created and 15985 entries were updated

2) Changes in the DR lines

2a) Cross-references were added to the cell line elements in the BioGRID Open Repository of CRISPR Screens (BioGRID_ORCS).

Corresponding entry in the file cellosaurus_xrefs.txt:

Abbrev: BioGRID_ORCS_Cell_line
Name  : BioGRID Open Repository of CRISPR Screens cell lines
Server: https://orcs.thebiogrid.org/
Db_URL: https://orcs.thebiogrid.org/Search?searchType=10&search=%s&organism=all
Term. : No
Cat   : CRISP screens repositories
//

Example:
DR   BioGRID_ORCS_Cell_line; 95

2b) Cross-references were added to the Developmental Studies Hybridoma Bank (DSHB). Prevously web links were provided to this resources, but we upgraded them to cross-references.

Corresponding entry in the file cellosaurus_xrefs.txt:

Abbrev: DSHB
Name  : Developmental Studies Hybridoma Bank
Server: https://dshb.biology.uiowa.edu/
Db_URL: https://dshb.biology.uiowa.edu/%s
Term. : No
Cat   : Cell line collections (Providers)
//

Example:
DR   DSHB; 12-120-94-6

3) Changes in the XML file

Six new elements have been created:

knockout-cell
microsatellite-instability 
monoclonal-antibody-isotype
monoclonal-antibody-target
resistance
transformant

They allow a structured representation of the information which was formerly represented as the text comments: "Knockout cell", "Microsatellite instability", "Monoclonal antibody isotype", "Monoclonal antibody target", "Selected for resistance to" and "Transformant".

cell-line biocuration cellosaurus knowledgebase • 175 views
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