fold change value

Question

[Giovana]

In the context of protein fold change, if the value includes the symbol "-", does it mean that the protein is downregulated, indicating a decrease in expression compared to the control conditions?

Answer 1

[Ram]

Yes - it means the condition on the numerator has less quantity than the condition on the denominator. The fraction (fold-change) is < 1, making logFC < 0.