Question: Identifying Proteins (In A Disease) And Protein Targets (For Drugs)
gravatar for Shweta
9.4 years ago by
Shweta90 wrote:

How can I find proteins involved in a disease (I'm interested in epilepsy) and protein targets (for drugs) associated with it?

protein disease drug • 3.4k views
ADD COMMENTlink modified 9.4 years ago by Khader Shameer18k • written 9.4 years ago by Shweta90
gravatar for Lars Juhl Jensen
9.4 years ago by
Copenhagen, Denmark
Lars Juhl Jensen11k wrote:

With the danger of sounding snarky: did you try Google? Less than five minutes got me this far.

Genetics of epilepsy:

Epilepsy drugs:

All you would have to do to find know drug targets is to look up the drugs from these lists in any of a number of general drug-target databases.

ADD COMMENTlink modified 9.4 years ago • written 9.4 years ago by Lars Juhl Jensen11k
gravatar for Khader Shameer
9.4 years ago by
Manhattan, NY
Khader Shameer18k wrote:

Nice suggestions by Lars and Lyco:

Here is what I would do:

Instead of using a single database, I will use three genetic disease resources and one generic disease resource and go for a union / intersection of the four database (depending on the stringency and class of epileps diseases you need for your analysis).

Genetic disease resource:

Generic disease annotation resource:

Along with target database suggested by Lars and Lyco, you can do some literature curation to see how many of them are actual drug targets. You may also check these literature curated resources for finding targets among your list of proteins involved in epilepsy.

ADD COMMENTlink modified 12 months ago by _r_am31k • written 9.4 years ago by Khader Shameer18k
gravatar for Lyco
9.4 years ago by
Lyco2.3k wrote:

Lars already pointed towards some epilepsy-specific resources. More generally, there are databases and search services that provide links between genes/proteins and disease conditions. Here are two that I use a lot: Fable and GoGene/GoDisease. Both work by pubmed mining, i.e. the genes that are returned are not necessarily causally involved in the disease but are often cited in this context. For most applications, this is what you need (and there is a big overlap with the causal genes). If you are really into causal genes, you should have a look at OMIM.

ADD COMMENTlink written 9.4 years ago by Lyco2.3k
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