i have worked with normal-tumor SNVs results by using VarScan2 and Mutect.
So I have total 500 candidate somatic nucleotide variants.
but problems is that there is so many snvs in my data. I need significant snvs which is related to cancer.
so i think that i have to search databases liek dbSNP or 1000genome.
so how to utilize above databases well? or Is there anything better method to find somatic variants in large sets?