**0**wrote:

We want to evaluate the association of several SNPs in an population with a disease. After the bech work we have a database with the results. We use the software PLINK to run logistic regression analysis including covariates like the sex of the patientcs. The output file give me several p-values :

My questions is: Which p-value give me the association between the SNP and the disease? which p-value reflect the effect of the covariate?

You'll need to either upload an image of that table somewhere or simply make a table in your post and manually type in the values.

93kThe output file is:

0.7

0Thank you so much for your help. I was totally lost with this kind of analysis because I thought that the ADD p-value was for SNP-disease interaction (the p-value is significant) and SEX p-value for Sex-disease association (not significant) but I do not understad the ADDxSEX colum (not significant and higher tan SEX-p-value) I mean with a P-value so high does it mean that SEX has influenced in the disease?? (because when SEX effect is added, the p-value change from significant to not significant)

I am totally lost

0Gender has an insignificant p-value, so no, it doesn't seem to influence anything here. "ADDxSEX" is looking at a possible interaction between the disease and gender, for which there also appears to be none. You might want to have a local statistician walk you through what a logistic regression is and what an interaction means.

93kThank you son much again...but the relation between the SNPs-disease corrected by sex, which analyse or p-value is??

Sorry for my ignorance, and thank you for your time and your help

0ADD is the SNP disease result while accounting for gender.

93k