Question: Computing PAM and Blosum Substitution Matrices
2
gravatar for psetha
4.6 years ago by
psetha90
Germany
psetha90 wrote:

Hello everyone!

This is my first post on here. Hope you guys can give a helping hand to me.

 

This semester I'm getting a computational biology course. I've been enjoying though being a biochemistry based student makes dealing with calculations and maths a bit challenging.

 

There's this homework I'm struggling with. http://web.iyte.edu.tr/~bilgekaracali/EE550/Homework%201.pdf

Even though I'm reading the text book I can't manage to find out how I am going to create PAM and BLOSUM matrices from the aminoacid sequence given. 

 

Can you show me a way out as I will keep searching for such examples but solved?

 

Thank you and sorry if I'm breaking some kind of forum rules by posting this, I just started to feel overwhelmed.

pam blosum • 1.8k views
ADD COMMENTlink modified 4.6 years ago by Woa2.7k • written 4.6 years ago by psetha90
1

Hi,

Though we don't encourage solving your homework for you, helping you out with pointers would not be a problem.

A small note: From the way you've phrased your question, it would seem that you think of the sequence in the assignment as a single sequence. Please note that each line is a different sequence and you have 20 sequences, each 100 aa long. This should help you with your first step towards building the matrices.

ADD REPLYlink written 4.6 years ago by RamRS21k
3
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