Hello,
I am using PLINK2 to create a profile score and am confused to what the output represent:
My score file has ~84k SNPs and my profile output looks like this
FID IID PHENO CNT CNT2 SCORE
00 1 1 173748 83462 0.017818
01 1 1 173740 83216 0.017095
02 2 1 173728 83738 0.017375
Plink says
CNT -Number of non-missing SNPs used for scoring
CNT2 -The number of named alleles
It seems to me that plink might have interchanged CNT and CNT2 column but I do not understand what "number of named alleles" mean ? Also, the scoring is such, all my individuals are scored in the range of 0.017095 to 0.017999, isn't that a bit strange ?
Many thanks
Thank you for your comment. I didn't quite get your statement "You can use the 'center' modifier to normalize them to have mean zero." -> what do you mean by center modifier?
Instead of just "--score [filename]", you can type "--score [filename] center".
Thank you, that helped but now some of my individuals have negative scores, does it mean that those individuals do not contribute to the diseased phenotype ?
If your score file is accurate, negative scores indicate lower risk and positive scores indicate higher risk.