Question: A question about rBiopaxParser
0
gravatar for sedaghat.nafiseh
4.8 years ago by
United States
sedaghat.nafiseh20 wrote:

Hi all,

Who knows what is the difference between the outputs of 'listPathwayComponents' and 'pathway2Geneset' in rBiopaxParser?

It seems that the 'listPathwayComponents' returns all interactions which are available in the corresponding pathway and 'pathwayGeneset' returns physical entities and 'BiochemicalReactions' in the corresponding pathway, as well.

When I use both of them for a given pathway id, BiochemicalReactions in the output of both instructions are different and just some of them are common.

Can anyone tell me why 'BiochemicalReactions' for a given pathway are different in these two instructions?

Thanks

Nafiseh

R biopax rbiopaxparser pathway • 1.0k views
ADD COMMENTlink modified 4.8 years ago by emekdemir100 • written 4.8 years ago by sedaghat.nafiseh20
2
gravatar for emekdemir
4.8 years ago by
emekdemir100
United States
emekdemir100 wrote:

Hi Nafiseh,

If you can post the owl files I might guess what the problem might be. I am suspecting nested pathways. But I don't develop/use rBioPAXParser so they would be at best guesses.

I also want to point out that there is another R library for acessing Pathways in BioPAX form - it is called PaxtoolsR, is in active development and it is based on the widely used Paxtools java library. You can find it here:

http://www.bioconductor.org/packages/release/bioc/html/paxtoolsr.html

Best,

ED

 

ADD COMMENTlink written 4.8 years ago by emekdemir100

Yes, you're right. It is because of nested pathways.

Thanks for introducing the 'paxtoolsr'. It is helpful.

ADD REPLYlink written 4.8 years ago by sedaghat.nafiseh20
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