Question: BETA(direction of effect) sign flipping based on the coded allele - when doing meta analysis of different studies - explain?
0
iphoenix2100 • 40 wrote:
Hi all,
So I am doing this new analysis (meta) from different studies. In which I was asked
- to swap the coded and non-coded alleles
- and the direction/sign of the beta flipped
to make both consistent across studies.
I am not able to understand this part or the reason why it is being done. can someone explain
Eg. Study 1:
|
SNP |
Coded allele |
Non coded allele |
Beta |
|
rs1 |
A |
T |
-0.5465 |
Study 2
|
SNP |
Coded allele |
Non coded allele |
Beta |
|
rs1 |
A |
T |
0.0345 |
ADD COMMENT
• link
•
modified 6.1 years ago
by
David W ♦ 4.8k
•
written
6.1 years ago by
iphoenix2100 • 40
