How do I annotate the protein effect of an in-frame insertion of a "TAG" stop codon inside a cDNA sequence?
Typically, I would annotate an insertion with something like: p.K2_L3insQ (insert a glutamine between the lysine at position 2 and the leucine at position 3). If the inserted sequence resulted in a stop codon, should I annotate it as p.K2_L3insX (or p.K2_L3ins*)? Alternatively, I can imagine a notation like p.K2K*. Are either of these standard or is something else used altogether?