5.4 years ago by
Washington University in St. Louis, MO
- Considering samples from the same patient 'replicates' is potentially dangerous. Spatial heterogeneity in solid tumors may mean that two samples have very different profiles.
- If the primary difference is just multiple platforms from the same tumor subsection, you can probably just use the highest-resolution method and call it a day.
- If you want to get complicated, you can look at this method out of Terry Speed's lab, but my feeling is that it's probably more hassle than it's worth, in general. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660872/