The coverage of a set of protein sequences to all possible human protein

Question

[ajingnk]

I have a set of protein sequences, and I want to know how much coverage of my set to all human protein sequences. I have sequences from UniProt also. Is that possible to draw a phylogenetic tree with all sequences from UniProt and highlight my sequence on the leaf of nodes? That will be a huge graph. I wonder whether you guys have seen such kind of work.

Answer 1

[Elisabeth Gasteiger]

I realize that this may not answer your question strictly speaking, but you may find this UniProt FAQ helpful:

"Is there a download file available where all UniProt IDs from X.laevis are matched to their human equivalents (homologs)? How can I obtain an ortholog mapping of human proteins to S.pombe proteins?"