What is the best method for selecting significant genes in one class expression profiles?

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9.1 years ago

Na Sed ▴ 310

I have one class gene expression which I want to find the most significant genes to do more precise analysis.

I saw somewhere which had defined a threshold and selected those gene which their expression were greater than the threshold. I am wondering is there any other method to do such analysis more precisely?

Thansk.

significance analysis gene expression • 1.5k views

ADD COMMENT • link updated 23 months ago by Ram 43k • written 9.1 years ago by Na Sed ▴ 310

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What is a "significant gene" in your experiment? What is the biological question you are trying to answer?

ADD REPLY • link updated 23 months ago by Ram 43k • written 9.1 years ago by Sean Davis 26k

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I am going to analyze miRNA-mRNA interactions through their expression profiles. In this regard, the number of mRNAs as well as miRNAs are too much, so I want to decrease the number of both and keep just those which have ,ore variability.

Thanks.

N

ADD REPLY • link 9.1 years ago by Na Sed ▴ 310

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