Question: number of transcription factor binding sites
0
gravatar for sasa
4.0 years ago by
sasa10
sasa10 wrote:

Hi all!

I use MEME to predict the transcription factor binding site, and it gives me a exact specific position.

I want to know a TF only binds to one specific place in a gene? How does a TF recognizes this position in such a long sequence.

Thanks! 

ADD COMMENTlink written 4.0 years ago by sasa10
2

There are quite a few things that affect protein binding to DNA. However most of that's rather off-topic for this site. While others might give you a sufficient answer (thus, I haven't closed this...though I wouldn't be surprised if someone else does), you're likely to receive a longer reply on the biology stack exchange. Please do do some research beforehand. The basics of this is are covered in undergrad genomics/molecular biology text-books (hint, look in the back index for major and minor grooves).

ADD REPLYlink written 4.0 years ago by Devon Ryan89k
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