number of transcription factor binding sites

Question

[sasa]

Hi all!

I use MEME to predict the transcription factor binding site, and it gives me a exact specific position.

I want to know a TF only binds to one specific place in a gene? How does a TF recognizes this position in such a long sequence.

Thanks!

[Devon Ryan]

There are quite a few things that affect protein binding to DNA. However most of that's rather off-topic for this site. While others might give you a sufficient answer (thus, I haven't closed this...though I wouldn't be surprised if someone else does), you're likely to receive a longer reply on the biology stack exchange. Please do do some research beforehand. The basics of this is are covered in undergrad genomics/molecular biology text-books (hint, look in the back index for major and minor grooves).