I would like to convert an amino acid variant to a DNA SNP call. Say you have protein A with mutation G100R, indicating a glycine to arginine switch at position 100.
Assuming the codon position is not in question, does anyone know of an available bioinformatics tool/script that will predict the DNA sequence change(s) causing the amino acid mutation. Ideally, the tool/script would 1) take into account human codon bias and 2) generate probabilities for each prediction?
Not a difficult piece of code to generate, but I would prefer not to reinvent the wheel.