We want to perform a linkage analysis study (using an Illumina SNP array) in a family affected with an autosomal dominant disorder
Could someone give some advice on how much family members (affected + unaffected) we would need? I suppose that the more family members you have, the better it is. And is it also necessary to genotype the unaffected parent of affected children? And what about the grandparents, do you need them both? I've read that most tools can handle missing data, but I'm not sure to what extent.
I've read that tools like MERLIN or PLINK are suited to perform the data analysis. Are there other recommended ones?