I am looking for a database that gives me information of mutations across human genome. Supposedly it works like this: I submit a file containing the genomic physical locations of a bunch of mutations I am interested in, and I get reply from the database telling me the type of each mutation, i.e. synonymous, frame shift, missense or nonsynonymous. Could you suggest such a database?
Kindest regards, Gao
PS: the interest is ANY real single base mutation, not confined to SNPs, and not predicted by tools like Polyphen
Have you tried : HGMD : Human Gene Mutation Database?
Thanks Khader, this looks a hopeful one! I'll dig into it.