NCBI database on a nucleotide search returning multiple repeats of the same CDSs
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8.9 years ago
shawncho ▴ 100

Hello,

I had a quick question regarding CDS listing from the nucleotide database. I looked up my query:

http://www.ncbi.nlm.nih.gov/nuccore/825206210

and as I scrolled down to see the CDS's, I found 7. The first two are unique, but CDS's 3-7 are the same exact sequences, but with different protein_id's. At first I thought maybe these were different transcripts, but they all appear to have the same protein sequence as well.

What does this mean? I was thinking it's the same sequence that was duplicated when sequencing, but I'm not sure why there are five of the same regions listed - seems redundant.

Thank you!

ncbi database • 1.4k views
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Entering edit mode
8.8 years ago
Juke34 8.6k

Hi,

They are different transcripts (isoforms) of the same gene, but they differ in their structures not in their sequences (not so common)

 /transcript_id="[XM_012665993.1](http://www.ncbi.nlm.nih.gov/nuccore/826407005)"
..
  [mRNA](http://www.ncbi.nlm.nih.gov/nuccore/825206210?itemid=11&sat=4&sat_key=140986362)            complement(join(20155..20875,20969..21123,21291..21522,
                     21625..22789,22925..23379,23492..23625))
#                                        ^^^^^ ^^^^^
..
 /transcript_id="[XM_012665913.1](http://www.ncbi.nlm.nih.gov/nuccore/826407003)"
..
     [mRNA](http://www.ncbi.nlm.nih.gov/nuccore/825206210?itemid=10&sat=4&sat_key=140986362)            complement(join(20155..20875,20969..21123,21291..21522,
                     21625..22789,22925..23409,23496..23625))
#                                        ^^^^^ ^^^^^
..
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