NCBI database on a nucleotide search returning multiple repeats of the same CDSs

Question

[shawncho]

Hello,

I had a quick question regarding CDS listing from the nucleotide database. I looked up my query:

http://www.ncbi.nlm.nih.gov/nuccore/825206210

and as I scrolled down to see the CDS's, I found 7. The first two are unique, but CDS's 3-7 are the same exact sequences, but with different protein_id's. At first I thought maybe these were different transcripts, but they all appear to have the same protein sequence as well.

What does this mean? I was thinking it's the same sequence that was duplicated when sequencing, but I'm not sure why there are five of the same regions listed - seems redundant.

Thank you!

Answer 1

[Juke34]

Hi,

They are different transcripts (isoforms) of the same gene, but they differ in their structures not in their sequences (not so common)

 /transcript_id="[XM_012665993.1](http://www.ncbi.nlm.nih.gov/nuccore/826407005)"
..
  [mRNA](http://www.ncbi.nlm.nih.gov/nuccore/825206210?itemid=11&sat=4&sat_key=140986362)            complement(join(20155..20875,20969..21123,21291..21522,
                     21625..22789,22925..23379,23492..23625))
#                                        ^^^^^ ^^^^^
..

 /transcript_id="[XM_012665913.1](http://www.ncbi.nlm.nih.gov/nuccore/826407003)"
..
     [mRNA](http://www.ncbi.nlm.nih.gov/nuccore/825206210?itemid=10&sat=4&sat_key=140986362)            complement(join(20155..20875,20969..21123,21291..21522,
                     21625..22789,22925..23409,23496..23625))
#                                        ^^^^^ ^^^^^
..