I only have RPKM data from RNA-seq now, and want to make it for hierarchical clustering.
My question is whether I need to apply the log transformation for the RPKM data before the clustering? or I can directly calculate the zscore for the data to do clustering.
I have this question because I think the goal for log transformation is to scale the ratio of change, especially for microarray data. Since the data I have now is not a ratio, I think maybe no need to do this transformation.