Hi, could anybody help me about how to link disease-associated genes and DEGs in a PPI network? and what's more, identify meaningful biological pathways or modules by using some approaches? the software/plugins and steps?
Here is my problem:
(1) a list of disease-associated genes from GWAS study and a list of genes which expressed deferentially btw. cases/controls, the two lists are quite different, indeed, which means there is nearly no overlap btw the two lists.
(2) I throw them in a PPI network.
(3) how to link the two lists in a meaningful way and spawn some functional modules?
Thank you so much!!!