What are the good tools for mRNA codon usage optimization and secondary structure prediction?
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7.2 years ago
jack ▴ 940

Hi all,

 

I'm looking for tool to do codon usage optimization for mRNAs and secondary structure prediction;

Basically I need to optimize codon usage to increase expression of the gene in host cell. Also I need to confirm that in the new sequence ribosome binding site are exposed and it's not involved in any secondary structure.

Would someone recommend some tools ?

genomicas bioinformatics • 2.1k views
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7.2 years ago
Asaf 9.3k

You can use RNAup for your second task, it gives an accessibility value for each window. 

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