Question: Simulate 1, 3 Copies
1
gravatar for Ann
7.7 years ago by
Ann10
Ann10 wrote:

Dear all,

Is there any tools that can simulate 1, 3, 7..CNVs?

Thanks!

Ann

next-gen sequencing • 1.4k views
ADD COMMENTlink written 7.7 years ago by Ann10
2

simulate reads? you need to provide more information on what it is you want to simulate.

ADD REPLYlink written 7.7 years ago by Damian Kao15k
1
gravatar for Neilfws
7.7 years ago by
Neilfws48k
Sydney, Australia
Neilfws48k wrote:

I suggest you search Google and/or PubMed for the terms "copy number variation" and "simulated data." There is a lot of literature on CNV detection and the authors often generate simulated data in order to test their algorithms. A good article will give details of the simulation process.

ADD COMMENTlink written 7.7 years ago by Neilfws48k
0
gravatar for Ann
7.7 years ago by
Ann0
Ann0 wrote:

Thanks!

@DK: Sorry! I didn't give enough information, simulating paired-end reads.

I inserted and deleted some regions of fasta files to make CNVs of genes; after that Wgsim to simulate.

But I'd like to look for a software making real CNVs, especially: heterogeneous copy numbers.

ADD COMMENTlink modified 7.7 years ago by iw9oel_ad6.0k • written 7.7 years ago by Ann0

If you have more information to add, please edit your original question instead of putting it here. This helps maintain the quality of Biotstar's answers. Thanks.

ADD REPLYlink written 7.7 years ago by iw9oel_ad6.0k
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