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Question: Simulate 1, 3 Copies
1
gravatar for Ann
7.7 years ago by
Ann • 10
Ann • 10 wrote:

Dear all,

Is there any tools that can simulate 1, 3, 7..CNVs?

Thanks!

Ann
next-gen sequencing • 1.4k views
ADD COMMENT • link •
written 7.7 years ago by Ann • 10
2

simulate reads? you need to provide more information on what it is you want to simulate.

ADD REPLY • link written 7.7 years ago by Damian Kao ♦ 15k
1
gravatar for Neilfws
7.7 years ago by
Neilfws ♦ 48k
Sydney, Australia
Neilfws ♦ 48k wrote:

I suggest you search Google and/or PubMed for the terms "copy number variation" and "simulated data." There is a lot of literature on CNV detection and the authors often generate simulated data in order to test their algorithms. A good article will give details of the simulation process.
ADD COMMENT • link written 7.7 years ago by Neilfws ♦ 48k
0
gravatar for Ann
7.7 years ago by
Ann • 0
Ann • 0 wrote:

Thanks!

@DK: Sorry! I didn't give enough information, simulating paired-end reads.

I inserted and deleted some regions of fasta files to make CNVs of genes; after that Wgsim to simulate.

But I'd like to look for a software making real CNVs, especially: heterogeneous copy numbers.
ADD COMMENT • link modified 7.7 years ago by iw9oel_ad ♦ 6.0k • written 7.7 years ago by Ann • 0

If you have more information to add, please edit your original question instead of putting it here. This helps maintain the quality of Biotstar's answers. Thanks.

ADD REPLY • link written 7.7 years ago by iw9oel_ad ♦ 6.0k
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