Parkinson disease databases

Question

[Bioinformatist Newbie]

Does anybody know databases with potential information on blood samples of Parkinson's disease patients (mainly at early stages)?

I know following, but I was wondering if something other than these is out there.

PDbase, PD Mutation Database, ParkDB

[pengchy]

1. You could check several review papers of the transcriptome analysis:

Redensek, S., et al. (2018). "From Genomics to Omics Landscapes of Parkinson's Disease: Revealing the Molecular Mechanisms." OMICS 22(1): 1-16. Borrageiro, G., et al. (2018). "A review of genome-wide transcriptomics studies in Parkinson's disease." Eur J Neurosci 47(1): 1-16.

Allen, M., et al. (2016). "Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases." Sci Data 3: 160089.

Walsh, M. J., et al. (2015). "Invited review: decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art." Neuropathol Appl Neurobiol 41(2): 109-134.

Hofmann-Apitius, M., et al. (2015). "Bioinformatics Mining and Modeling Methods for the Identification of Disease Mechanisms in Neurodegenerative Disorders." Int J Mol Sci 16(12): 29179-29206.

Cooper-Knock, J., et al. (2012). "Gene expression profiling in human neurodegenerative disease." Nat Rev Neurol 8(9): 518-530.

Caudle, W. M., et al. (2010). "Using 'omics' to define pathogenesis and biomarkers of Parkinson's disease." Expert Rev Neurother 10(6): 925-942.

2. ParkDB is unavailable now.

Answer 1

[Kevin Blighe]

Yes, there is now this database that has a wealth of information (but access is controlled):

• Parkinson's Progression Markers Initiative (PPMI)

Kevin