We are seeking a bioinformatics postdoctoral fellow to work under the direct supervision of Dr. Daniel De Carvalho at the Princess Margaret Cancer Centre - University of Toronto.
Our lab is using and developing cutting edge experimental and computational methods based on epigenomics, immunology and advanced cellular biology. Our previous work was recently published at Cell and laid the ground to the combination of epigenetic therapy with cancer immunotherapy. This work was highlighted by Nature Medicine as a 'notable advance in 2015' (http://bit.ly/1meYrxH). The selected candidate will work in a project focused on analyzing large data-sets from experimental and clinical samples to investigate the effects of epigenetic therapy on cancer cell and on the immune system.
The Princess Margaret Cancer Centre is one of the top cancer research centers in North America, and the University of Toronto consistently rank among the top universities in the World. Toronto is a vibrant city, with an exciting scientific community, and consistently ranked among the most livable cities in the world (http://bit.ly/1Kzwx9J and http://econ.st/1E1ntIF)
Qualifications:
- Ph.D in Bioinformatics or related areas;
- Knowledge of epigenetics would be an asset;
- Experience in analyzing high throughput epigenomics and transcriptomics datasets, including WGBS, ChIP-seq and RNA-seq;
- Experience with analytic tools such as R or Matlab;
- Demonstrated excellent publication record of scientific achievement;
- Excellent verbal and written communication skills;
- Motivation to solve complex biological problems, especially in the field of epigenomics;
- Highly motivated and self-driven to address challenging questions in the field of epigenomics.
Benefits: Includes extended medical insurance, dental insurance, maternity benefits, parental benefits, defined-benefit pension plan, and employment insurance.
For consideration, please send a CV, a brief statement of scientific/research interests, contact information for three references and start date availability to: epigenome.search@gmail.com
For more info: http://decarvalholab.org/
Selected publications:
- David Roulois, Helen Loo Yau, Rajat Singhania, Yadong Wang, Arnavaz Danesh, Shu Yi Shen, Han Han, Gangning Liang, Trevor J. Pugh, Peter A. Jones, Catherine O'Brien, Daniel De Carvalho. DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts. Cell. 2015 Aug 27;162(5):961-73.
- Yang X et al. Gene Body Methylation can Alter Gene Expression and is a Therapeutic Target in Cancer. Cancer Cell. 2014 Oct 13;26(4):577-90.
- De Carvalho DD et al. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell. 2012 May 15;21(5):655-67.
- Kelly TK et al. Epigenetic modifications as therapeutic targets. Nat Biotechnol. 2010 Oct 13;28(10):1069-1078.
