Question: Database of disease gene expression signatures?
gravatar for hexamer
3.0 years ago by
hexamer10 wrote:

Dear Bioinformatics gurus: Is there any downloadable database of disease-vs-normal gene expression profiles?

For each disease, this would be a list of all probesets with a fold-change and p-value.

Context: The BioConductor package "ConnectivityMap" contains a matrix (rankMatrix) of drug gene expression profiles. However, I am interested in disease gene expression profiles (from microarray experiments of disease versus normal tissues). A ranked matrix would suffice, but a list with fold-change and p-value would be best.

I would apply this for drug repositioning by performing GSEA using as input the up- and down-regulated genes from my specific drug of interest.

Thanks in advance!

ADD COMMENTlink modified 2.8 years ago by Biostar ♦♦ 20 • written 3.0 years ago by hexamer10
gravatar for EagleEye
3.0 years ago by
EagleEye6.2k wrote:

Genevisible from genevestigator is free

ADD COMMENTlink written 3.0 years ago by EagleEye6.2k
gravatar for WouterDeCoster
3.0 years ago by
WouterDeCoster37k wrote:

I believe (perhaps not freely) offers what you are looking for.

ADD COMMENTlink written 3.0 years ago by WouterDeCoster37k
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