Is there any reason to analyze plus/minus strands separately in bisulfite seq/methylation data?

Question

[biohack92]

I have bisulfite sequencing data that consists of read count data. The data is split based on strand orientation (plus & minus). What sort of questions can be answered by analyzing the plus/minus strand separately?

Answer 1

[Devon Ryan]

The only normal reasons are to test for asymmetric methylation and to see if one particular base in a motif is methylated or not (this can alter factor binding).

Answer 2

[Antonio R. Franco]

In plants, it has been described a non symmetrical methylation in domains other than CpG, such as CHH or CHG See this paper