Tools for protein networks building
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5.0 years ago
Bnf83 ▴ 150

Hi guys, I need to create a network of interacting proteins from MS expression measurements. Do you know which tools, softwares and algorithms are available to do this?

Thank you in advance

networks proteins systems biology algorithms • 1.3k views
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Don't you need interaction data, instead of expression data, in order to do this? Like yeast two hybrid for instance?

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Hi. I only have protein expression data from a MS experiment.

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5.0 years ago
natasha.sernova ★ 3.9k

Look at this paper:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086107/

NetworkAnalyst - integrative approaches for protein–protein interaction network analysis and visual exploration

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5.0 years ago
jiwpark00 ▴ 210

You can use Cytoscape. Granted, you are going to first need interaction data - which proteins are already interacting with what, etc.. Then you can use your expression data as a way to weigh the strength of each interaction.

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5.0 years ago
Bnf83 ▴ 150

Thank you very much guys!

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