Question: What isthe Indication of copy number?
gravatar for andrew.samy.abdelmalak
11 weeks ago by

What does a copy number of 4.4 indicate? Why is it decimal not integer?

Thank you very much.

dna copy number gene • 160 views
ADD COMMENTlink modified 11 weeks ago by Devon Ryan60k • written 11 weeks ago by andrew.samy.abdelmalak0

It is always helpful if you provide some background information. What data is it? Where did you get this number from?

ADD REPLYlink written 11 weeks ago by Vijay Lakhujani560
gravatar for Devon Ryan
11 weeks ago by
Devon Ryan60k
Freiburg, Germany
Devon Ryan60k wrote:
  1. There's variability attached, so it could be 4.4 +/- 0.4 or something like that.
  2. There's underlying cellular heterogeneity, so some cells have 4 copies, others 5.
  3. There's a bit of bias in the sequencing, so the estimates a bit higher/lower than what is actually happening.

Those are the first 3 possibilities that popped into my mind.

ADD COMMENTlink written 11 weeks ago by Devon Ryan60k
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