Question: What isthe Indication of copy number?
0
gravatar for andrew.samy.abdelmalak
11 months ago by

What does a copy number of 4.4 indicate? Why is it decimal not integer?

Thank you very much.

dna copy number gene • 390 views
ADD COMMENTlink modified 11 months ago by Devon Ryan71k • written 11 months ago by andrew.samy.abdelmalak0
1

It is always helpful if you provide some background information. What data is it? Where did you get this number from?

ADD REPLYlink written 11 months ago by Vijay Lakhujani1.3k
0
gravatar for Devon Ryan
11 months ago by
Devon Ryan71k
Freiburg, Germany
Devon Ryan71k wrote:
  1. There's variability attached, so it could be 4.4 +/- 0.4 or something like that.
  2. There's underlying cellular heterogeneity, so some cells have 4 copies, others 5.
  3. There's a bit of bias in the sequencing, so the estimates a bit higher/lower than what is actually happening.

Those are the first 3 possibilities that popped into my mind.

ADD COMMENTlink written 11 months ago by Devon Ryan71k
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1393 users visited in the last hour