Question: What isthe Indication of copy number?
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gravatar for andrew.samy.abdelmalak
3 months ago by

What does a copy number of 4.4 indicate? Why is it decimal not integer?

Thank you very much.

dna copy number gene • 185 views
ADD COMMENTlink modified 3 months ago by Devon Ryan62k • written 3 months ago by andrew.samy.abdelmalak0
1

It is always helpful if you provide some background information. What data is it? Where did you get this number from?

ADD REPLYlink written 3 months ago by Vijay Lakhujani560
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gravatar for Devon Ryan
3 months ago by
Devon Ryan62k
Freiburg, Germany
Devon Ryan62k wrote:
  1. There's variability attached, so it could be 4.4 +/- 0.4 or something like that.
  2. There's underlying cellular heterogeneity, so some cells have 4 copies, others 5.
  3. There's a bit of bias in the sequencing, so the estimates a bit higher/lower than what is actually happening.

Those are the first 3 possibilities that popped into my mind.

ADD COMMENTlink written 3 months ago by Devon Ryan62k
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