17 months ago by
- There's variability attached, so it could be 4.4 +/- 0.4 or something like that.
- There's underlying cellular heterogeneity, so some cells have 4 copies, others 5.
- There's a bit of bias in the sequencing, so the estimates a bit higher/lower than what is actually happening.
Those are the first 3 possibilities that popped into my mind.