Question: What isthe Indication of copy number?
gravatar for andrew.samy.abdelmalak
17 months ago by

What does a copy number of 4.4 indicate? Why is it decimal not integer?

Thank you very much.

dna copy number gene • 487 views
ADD COMMENTlink modified 17 months ago by Devon Ryan78k • written 17 months ago by andrew.samy.abdelmalak0

It is always helpful if you provide some background information. What data is it? Where did you get this number from?

ADD REPLYlink written 17 months ago by Vijay Lakhujani1.9k
gravatar for Devon Ryan
17 months ago by
Devon Ryan78k
Freiburg, Germany
Devon Ryan78k wrote:
  1. There's variability attached, so it could be 4.4 +/- 0.4 or something like that.
  2. There's underlying cellular heterogeneity, so some cells have 4 copies, others 5.
  3. There's a bit of bias in the sequencing, so the estimates a bit higher/lower than what is actually happening.

Those are the first 3 possibilities that popped into my mind.

ADD COMMENTlink written 17 months ago by Devon Ryan78k
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