Question: Drugs with unknown mechanism of action
gravatar for khorms
22 months ago by
khorms30 wrote:

I want to get a list of FDA-approved drugs with unknown mechanism of action. I think that there should be a database where for each drug there is a short field "mechanism", but I haven't find one. Do you know any database where I can find such information? Another possible way is to use text-mining programs to analyze scientific libraries like PubMed and find the drugs which names often occur together with words "mechanism" and "unknown". Are there any good programs which can do it? Any other suggestions are welcome too, of course.

ADD COMMENTlink modified 22 months ago by Zhilong Jia1.4k • written 22 months ago by khorms30

Have you tried ChEMBL? FLIBANSERIN is one of their drugs with no known mechanism of action. The data is manually curated from DailyMed.

ADD REPLYlink written 13 months ago by Denise - Open Targets4.6k
gravatar for Zhilong Jia
22 months ago by
Zhilong Jia1.4k
Zhilong Jia1.4k wrote:



ADD COMMENTlink written 22 months ago by Zhilong Jia1.4k

Thank you! Although, the links they provide in the field "Mechanism Of Action and Pharmacodynamic Effects " are pretty old. Do you know how often do they update the annotation? Do you know some other databases too?

ADD REPLYlink written 22 months ago by khorms30
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