Question: Drugs with unknown mechanism of action
gravatar for khorms
4.0 years ago by
khorms210 wrote:

I want to get a list of FDA-approved drugs with unknown mechanism of action. I think that there should be a database where for each drug there is a short field "mechanism", but I haven't find one. Do you know any database where I can find such information? Another possible way is to use text-mining programs to analyze scientific libraries like PubMed and find the drugs which names often occur together with words "mechanism" and "unknown". Are there any good programs which can do it? Any other suggestions are welcome too, of course.

ADD COMMENTlink modified 7 months ago by David Gortler20 • written 4.0 years ago by khorms210

Have you tried ChEMBL? FLIBANSERIN is one of their drugs with no known mechanism of action. The data is manually curated from DailyMed.

ADD REPLYlink written 3.3 years ago by Denise CS5.1k
gravatar for David Gortler
7 months ago by
United States
David Gortler20 wrote:

FYI, >>half of the drugs approved by the FDA have mechanisms of action "that have not ben fully elucidated" per official labeling. Its not a regulatory requirement for approval.

ADD COMMENTlink written 7 months ago by David Gortler20
gravatar for Zhilong Jia
4.0 years ago by
Zhilong Jia1.6k
Zhilong Jia1.6k wrote:



ADD COMMENTlink written 4.0 years ago by Zhilong Jia1.6k

Thank you! Although, the links they provide in the field "Mechanism Of Action and Pharmacodynamic Effects " are pretty old. Do you know how often do they update the annotation? Do you know some other databases too?

ADD REPLYlink written 4.0 years ago by khorms210
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