Question: Drugs with unknown mechanism of action
0
gravatar for khorms
2.1 years ago by
khorms30
Moscow
khorms30 wrote:

I want to get a list of FDA-approved drugs with unknown mechanism of action. I think that there should be a database where for each drug there is a short field "mechanism", but I haven't find one. Do you know any database where I can find such information? Another possible way is to use text-mining programs to analyze scientific libraries like PubMed and find the drugs which names often occur together with words "mechanism" and "unknown". Are there any good programs which can do it? Any other suggestions are welcome too, of course.

ADD COMMENTlink modified 2.1 years ago by Zhilong Jia1.4k • written 2.1 years ago by khorms30

Have you tried ChEMBL? FLIBANSERIN is one of their drugs with no known mechanism of action. The data is manually curated from DailyMed.

ADD REPLYlink written 15 months ago by Denise - Open Targets4.7k
0
gravatar for Zhilong Jia
2.1 years ago by
Zhilong Jia1.4k
London
Zhilong Jia1.4k wrote:

The IUPHAR/BPS Guide to PHARMACOLOGY

ref: http://nar.oxfordjournals.org/content/42/D1/D1098.abstract

http://guidetopharmacology.org/

ADD COMMENTlink written 2.1 years ago by Zhilong Jia1.4k

Thank you! Although, the links they provide in the field "Mechanism Of Action and Pharmacodynamic Effects " are pretty old. Do you know how often do they update the annotation? Do you know some other databases too?

ADD REPLYlink written 2.1 years ago by khorms30
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1678 users visited in the last hour