Question: Comparison of MeDIP data with transcriptomics expression data
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gravatar for saripalligautam86
2.2 years ago by
saripalligautam860 wrote:

Hello All,

I wanted to compare the methylation data with expression data. Can I compare the methylated counts of individual genes from whole genome methylation file ( of MeDIP seq data) with that of fpkm values of expression for the same gene which is common in medip and transcriptomics data and then infer the correlation differential methylation/expression based on this comparison?

Regards,

rna seq medip • 599 views
ADD COMMENTlink written 2.2 years ago by saripalligautam860

How many samples you have? Do you have control and treated sample?

One thing you can do is first check for the percentage of the methylated region in different sites.

Intergenic Site Intron Site Exon Site promoter-TSS(Transcription Start Site ) TTS (Transcription Termination Site)

Mostly the methylation should be observed in TSS site. Then for the Particular genes, you can do your case studies like hyper and hypo Methylation. And lastly, you can compare with your Transcriptome data.

Hope this might help you.

ADD REPLYlink written 2.2 years ago by mks002160
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