I know in edgeR, in multivariate analysis, you can do "ceof=3:5" to test and get p-values for genes that are differentially expressed under ANY of the conditions specified by "coef=3:5". My understanding is that "ANY" here means OR? Meaning if a gene is differentially expressed in either condition 3 or 4 or 5 being compared to the control (constant term), then it would be shown significant as indicated by its p-value. How if I want to find DEGs that are expressed in 3 AND 4 AND 5? How to setup the parameters? I know you can make condition 3 & 4 & 5 to be one condition and test for it, but this is a little bit cumbersome. If you can use something like "coef=3:5" on the fly, it would awesome.
Thanks in advance!