Question: Gene annotation from genomic features
gravatar for chiefcat
2.8 years ago by
chiefcat140 wrote:

Hi guys,

I've a got basic question regarding gene annotation.

What kind of genomic features can be assigned to genes (other than TSS, TTS, exon, intron, enhancer)? Thanks!


rna-seq chip-seq annotation • 797 views
ADD COMMENTlink modified 2.8 years ago • written 2.8 years ago by chiefcat140
gravatar for Alex Reynolds
2.8 years ago by
Alex Reynolds30k
Seattle, WA USA
Alex Reynolds30k wrote:

The GFF3 site offers a specification document with 1916 feature type categories and their descriptions/definitions.

For example:

id: SO:0000188
name: intron
def: "A region of a primary transcript that is transcribed, but removed from within the transcript by splicing together the sequences (exons) on either side of it." []
comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology.
subset: SOFA
xref: "wiki"
is_a: SO:0000835 ! primary_transcript_region


id: SO:0000198
name: noncoding_exon
def: "An exon that does not contain any codons." [SO:ke]
subset: SOFA
synonym: "noncoding exon" EXACT []
is_a: SO:0000147 ! exon


I suppose the real answer is that it depends on what format of gene annotation data you're working with. Anything goes, so long as people agree to use your standard.

ADD COMMENTlink modified 2.8 years ago • written 2.8 years ago by Alex Reynolds30k
gravatar for Jean-Karim Heriche
2.8 years ago by
EMBL Heidelberg, Germany
Jean-Karim Heriche22k wrote:

From the top my head: promoters, enhancers, chromatin states, DNA modifications (e.g. methylation), variations (SNPs, CNVs), gene type (e.g. coding/non-coding ...). There's probably more. Just look at annotated genomes in Ensembl to get ideas.

ADD COMMENTlink written 2.8 years ago by Jean-Karim Heriche22k
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