Question: Rare variant analysis
0
gravatar for Sharon
9 months ago by
Sharon340
Sharon340 wrote:

I started doing some rare variant association analysis tests like burden tests and other types. Some methods say whether it suits risk-increasing and risk-decreasing variants . I don't understand what is the meaning of risk increasing versus risk decreasing variants? Thanks

rare variants • 264 views
ADD COMMENTlink modified 9 months ago by WouterDeCoster30k • written 9 months ago by Sharon340
3
gravatar for WouterDeCoster
9 months ago by
Belgium
WouterDeCoster30k wrote:

Well, ehm, to me it's pretty self-explanatory:

  • a risk-increasing variant increases your risk to get a certain disease
  • a risk-decreasing variant decreases your risk to get a certain disease

Does that help? What's unclear exactly?

ADD COMMENTlink written 9 months ago by WouterDeCoster30k

I think I did not clarify my question correctly. So, when they say 'this given approach works when variants have the same direction', by same direction they mean all variants are risk increasing or all variants are risk decreasing?

ADD REPLYlink modified 9 months ago • written 9 months ago by Sharon340

Yes - that's what it means. In that case, if you have both risk-increasing and risk-decreasing variants your test will not work.

ADD REPLYlink written 9 months ago by WouterDeCoster30k

OK, Got it. Many thanks

ADD REPLYlink written 9 months ago by Sharon340

If an answer was helpful you should upvote it, if the answer resolved your question you should mark it as accepted. Upvote|Bookmark|Accept

ADD REPLYlink written 9 months ago by WouterDeCoster30k
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