Question: Rare variant analysis
0
gravatar for Sharon
10 days ago by
Sharon30
Sharon30 wrote:

I started doing some rare variant association analysis tests like burden tests and other types. Some methods say whether it suits risk-increasing and risk-decreasing variantsĀ . I don't understand what is the meaning of risk increasing versus risk decreasing variants? Thanks

rare variants • 118 views
ADD COMMENTlink modified 10 days ago by WouterDeCoster22k • written 10 days ago by Sharon30
2
gravatar for WouterDeCoster
10 days ago by
Belgium
WouterDeCoster22k wrote:

Well, ehm, to me it's pretty self-explanatory:

  • a risk-increasing variant increases your risk to get a certain disease
  • a risk-decreasing variant decreases your risk to get a certain disease

Does that help? What's unclear exactly?

ADD COMMENTlink written 10 days ago by WouterDeCoster22k

I think I did not clarify my question correctly. So, when they say 'this given approach works when variants have the same direction', by same direction they mean all variants are risk increasing or all variants are risk decreasing?

ADD REPLYlink modified 9 days ago • written 9 days ago by Sharon30

Yes - that's what it means. In that case, if you have both risk-increasing and risk-decreasing variants your test will not work.

ADD REPLYlink written 9 days ago by WouterDeCoster22k

OK, Got it. Many thanks

ADD REPLYlink written 9 days ago by Sharon30

If an answer was helpful you should upvote it, if the answer resolved your question you should mark it as accepted. Upvote|Bookmark|Accept

ADD REPLYlink written 4 days ago by WouterDeCoster22k
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