Are there any tools to simulate mutations?

Question

[MAPK]

I am working on a gene mutation method. I am trying to test my tool using 1000 genome vcf file (multigenome vcf file). I am using only one chromosome(as that should be enough to test my algorithm). I now want to simulate mutations in ~10 samples of 1K genome project vcf file. Can someone please suggest me a tool that can be used to simulate mutation in a multgenome vcf file?

Answer 1

[Gabriel R.]

msprime (https://github.com/jeromekelleher/msprime). You can simulate a demography of say 10 individuals and output segregating sites as VCF. You can even plug in a recombination map.