Are there any tools to simulate mutations?
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6.7 years ago
MAPK ★ 2.1k

I am working on a gene mutation method. I am trying to test my tool using 1000 genome vcf file (multigenome vcf file). I am using only one chromosome(as that should be enough to test my algorithm). I now want to simulate mutations in ~10 samples of 1K genome project vcf file. Can someone please suggest me a tool that can be used to simulate mutation in a multgenome vcf file?

vcf mutation • 2.0k views
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Entering edit mode
6.7 years ago
Gabriel R. ★ 2.9k

msprime (https://github.com/jeromekelleher/msprime). You can simulate a demography of say 10 individuals and output segregating sites as VCF. You can even plug in a recombination map.

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