Question: Are there any tools to simulate mutations?
0
gravatar for MAPK
14 months ago by
MAPK1.3k
United States
MAPK1.3k wrote:

I am working on a gene mutation method. I am trying to test my tool using 1000 genome vcf file (multigenome vcf file). I am using only one chromosome(as that should be enough to test my algorithm). I now want to simulate mutations in ~10 samples of 1K genome project vcf file. Can someone please suggest me a tool that can be used to simulate mutation in a multgenome vcf file?

mutation vcf • 638 views
ADD COMMENTlink modified 14 months ago by Gabriel R.2.5k • written 14 months ago by MAPK1.3k
2
gravatar for Gabriel R.
14 months ago by
Gabriel R.2.5k
Center for Geogenetik Københavns Universitet
Gabriel R.2.5k wrote:

msprime (https://github.com/jeromekelleher/msprime). You can simulate a demography of say 10 individuals and output segregating sites as VCF. You can even plug in a recombination map.

ADD COMMENTlink written 14 months ago by Gabriel R.2.5k
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